GARIBOLDI MARZIA BRUNA | Università degli studi dell'Insubria

E-mail

[email protected]

Numero telefonico

0331 339 418

CURRICULUM STUDIORUM :

Luglio 1986

Maturità “ Tecnico delle Industrie Chimiche”, Istituto Professionale di Stato A. Pacinotti, Milano

22 Febbraio 1994

Laurea in Scienze Biologiche

Università di Milano, Facoltà di Scienze MMFFNN

(Tesi: Meccanismo dell’azione sinergica di Interleuchina-1 e Doxorubicina su cellule di carcinoma ovarico umano).

12 Luglio 2000

Specializzazione in Farmacologia

Università di Pavia, Facoltà di Medicina e Chirurgia

(Tesi: Effetto antiproliferativo in vitro e in vivo del nitrossido piperidinico TEMPOL su una linea cellulare di glioma).

PROFILO SINTETICO DELLA CARRIERA, FINANZIAMENTI PER LA RICERCA E SOGGIORNI ALL’ESTERO:

1994

Vincitore di una Borsa di Studio dell’Università di Milano per Corsi di Perfezionamento all’Estero per l’A.A. 1993/94.

Vincitore di un concorso a n.1 posti di Assistente Tecnico per le esigenze della Cattedra di Farmacologia Applicata della Facoltà di Scienze MMFFNN, Università di Milano

Nominata Assistente Tecnico, VI qualifica, presso l’Istituto di Farmacologia della Facoltà di Scienze MMFFNN

1995

Vincitore di un Contributo "Altri Interventi", Consiglio Nazionale delle Ricerche.

Guest Researcher presso il Laboratory of Molecular Pharmacology, Basic Science, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A.

1996

Confermata Assistente Tecnico, VI qualifica, presso l’Istituto di Farmacologia della Facoltà di Scienze MMFFNN.

1998

Vincitore di un premio per la qualità della prestazione individuale dell’Università degli Studi di Milano.

1999

Trasferita come Assistente Tecnico, VI qualifica, presso il DBSF - Sezione di Farmacologia dell’Università degli Studi dell’Insubria.

Vincitore di un concorso a n.1 posti di Ricercatore per le esigenze della Sezione di Farmacologia della Facoltà di Scienze MMFFNN, Università degli Studi dell’Insubria.

Nominata Ricercatore non confermato presso il DBSF - Sezione di Farmacologia, Facoltà di Scienze MMFFNN, Università degli Studi dell’Insubria.

2002

Nominata Ricercatore confermato presso il DBSF - Sezione di Farmacologia, Facoltà di Scienze MMFFNN, Università degli Studi dell’Insubria.

2012

Abilitazione Nazionale nel SSD BIO13 – Biologia Applicata.

2017

Partecipazione a una procedura valutativa per Professore Associato (SSD BIO13 – Biologia Applicata) presso l’Università degli Studi dell’Insubria.

AFFILIAZIONE A SOCIETÀ SCIENTIFICHE

- American Association for Cancer Research

- Associazione Italiana di Colture Cellulari

- Società Italiana di Farmacologia

- European Association for Cancer Reasearch

Portale IRInSubria

Pubblicazioni in evidenza

ELENCO DELLE PUBBLICAZIONI - Articoli

Gariboldi MB. Monti E. Antiproliferative effects of interleukin-1 a and nitric oxide release in a human ovarian carcinoma cell line. International Journal Oncology, 9: 499-503, 1996.

Dolfini E, Dasdia T, Arancia G, Molinari A, Calcabrini A, Scheper RJ, Flens MJ, Gariboldi MB, Monti E. Characterization of a clonal human colon adenocarcinoma line intrinsically resistant to doxorubicin. British Journal of Cancer, 76: 67-76, 1997.

Gariboldi MB, Lucchi S, Caserini C, Supino R, Oliva C, Monti E. Antiproliferative effect of the piperidine nitroxide TEMPOL on neoplastic and non-neoplastic mammalian cell lines. Free Radical Biology and Medicine, 24: 913-923, 1998.

Carrier F, Georgel PT, Pourquier P, Blake M, Kontny KH, Antinore MJ, Gariboldi M, Myers TG, Weinstein JN, Pommier Y, Fornace AJ Jr. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol. Cell. Biol. 19: 1673-1685, 1999.

Gariboldi MB, Rimoldi V, Supino R, Favini E, Monti E. The nitroxide TEMPOL induces oxidative stress, p21waf1/cip1 and cell death in HL60 cells. Free Radical Biology and Medicine 29:633-641, 2000.

Monti E, Supino R, Colleoni M, Costa B, Ravizza R, Gariboldi MB. The piperidine nitroxide TEMPOL impairs mitochondrial function and induces apoptosis in HL60 cells. J Cell Biochem 82: 271-276, 2001.

Gariboldi MB, Ravizza R, Marras E, Perletti G, De Simone A, Piccinini F, Monti E. Resistance of human leukemic cell lines to 1-b-D-arabinofuranosylcytosine: characterization of an experimental model. Int J Oncol 18:1245-1249, 2001.

Meschini S, Marra M, Calcabrini A, Monti E, Gariboldi M, Dolfini E, Arancia G. Role of the lung resistance related protein (LRP) in the drug sensitivity of cultured tumor cells. Toxicology in vitro 16: 389-398, 2002.

Gariboldi MB, Ravizza R, Petterino C, Castagnaro M, Finocchiaro G, Monti E. Study of in vitro and in vivo effects of the piperidine nitroxide Tempol—a potential new therapeutic agent for gliomas. European Journal of Cancer 39(6):829-37, 2003.

Gariboldi MB, Ravizza R, Riganti L, Meschini S, Calcabrini A, Arancia G, Dolfini E, Monti E. Molecular determinants of the doxorubicin intrinsic resistance (MDR) in human cancer cell lines. International J. Of Oncology 22(5):1057-64, 2003.

Banfi S, Caruso E, Caprioli S, Mazzagatti L, Canti G, Ravizza R, Gariboldi M, Monti E. Photodynamic Photodynamic effects of porphyrin and chlorin photosensitizers in human colon adenocarcinoma cells. Bioorg Med Chem. 12(18):4853-60, 2004.

Ravizza R, Cereda E, Monti E, Gariboldi MB. The piperidine nitroxide Tempol potentiates the cytotoxic effects of temozolomide in human glioblastoma cells. International J. Of Oncology 25(6):1817-22, 2004.

Ravizza R, Gariboldi MB, Pessarelli L, Monti E. Role of the p53/p21 system in the response of human colon carcinoma cells to Doxorubicin. Biomed Central Cancer 4: 92, 2004.

Monti E, Gariboldi M, Maiocchi A, Marengo E, Cassino C, Gabano E, Osella D. Cytotoxicity of platinum (II) conjugated model. The effect of chelating arms and leaving group on cytotoxicity: a QSAR approach. Journal of Medicinal Chemistry 48:857-866, 2005.

Ravera M, Cassino C, Monti E, Gariboldi M, Osella D. Enhancement of the cytotoxicity of titanocene dichloride by aging in organic co-solvent. Journal of Inorganic Biochemistry 99: 2264-2269, 2005.

Gariboldi MB, Terni F, Ravizza R, Meschini S, Marra M, Condello M, Arancia G, Monti E. The piperidine nitroxide Tempol modulates anthracycline resistance in mdr breast cancer cells. Free Radical Biology and Medicine 40: 1409-1418, 2006.

Banfi S, Caruso E, Fieri E, Buccafurni L, Gariboldi M, Ravizza R, Monti E. Synthesis and photodynamic activity of diaryl-porphyrins characterized by the presence of nitro groups. Journal of Porphyrins and Phthalocyanines 10: 1319, 2006.

Banfi S, Caruso E, Buccafurni L, Murano R, Monti E, Gariboldi M, Papa E, Grammatica P. Comparison Between 5,10,15,20-Tetraaryl- and 5,15-Diarylporphyrins as Photosensitizers: Synthesis, Photodynamic Activity and QSAR Investigation. J. Med. Chem. 49: 3293-3304, 2006.

Banfi S, Caruso E, Buccafurni L, Ravizza R, Gariboldi M, Monti E. Zinc phtalocyanines-mediated photodynamic therapy induces cell death in adenocarcinoma cells. Journal of Organometallic Chemistry. 692:1269-1276, 2007.

Gariboldi MB, Ravizza R, Molteni R, Osella D, Gabano E, Monti E. Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line. Cancer Letters 258: 181-188, 2007.

Banfi S, Caruso E, Gariboldi M, Alemani S, Nasini G, Bombardelli E. Synthesis of Porphyrin-Anthraquinone conjugates as photosensitizing agents. Synthetic Communications 38: 1096-1109, 2008.

Milanesio M, Monti E, Gariboldi MB, Gabano E, Ravera M, Osella D. Trend in Cytotoxic Activity of a series of cis-[APtCl2] (A = ethylenediamine methylated at different positions) Complexes. Inorganica Chimica Acta, 361: 2803-2814, 2008.

Ravizza R, Gariboldi MB, Molteni R, Monti E. Linalool, a plant-derived monoterpene alcohol, reverses doxorubicin resistance in human breast adenocarcinoma cells. Oncology Reports 20: 625-630, 2008.

Ravizza R, Molteni R, Gariboldi MB, Marras E, Perletti G, Monti E. Effect of HIF-1 modulation on the response of two- and three-dimensional cultures of human colon cancer cells to 5-fluorouracil. Eur. J Cancer 45:890-898, 2009.

Gariboldi MB, Ravizza R, Baranyai P, Caruso E, Banfi S, Meschini S, Monti E. Photodynamic Effects of Novel 5,15-Diaryl-Tetrapyrrole Derivatives on Human Colon Carcinoma Cell Lines. Bioorg. Med. Chem 17: 2009-2016, 2009.

Monti E, Gariboldi MB, Ravizza R, Molteni R, Gabano E, Sparnacci K, Laus M, Osella D. Poly(methylmetacrylate) (PMMA) core-shell nanospheres act as efficient pharmacophores for the antiproliferative [PtCl3(NH3)]- complex by forming ionic couples. Inorganica Chimica Acta 362: 4099-4109, 2009.

Caron G, Ermondi G, Gariboldi MB, Monti E, Gabano E, Ravera M, Osella D. The Relevance of Polar Surface Area (PSA) in Rationalizing Biological Properties of Several cis-Diamminemalonatoplatinum(II)-derivatives. Chem Med Chem 4:1677-1685, 2009.

Gariboldi MB, Ravizza R, Monti E. The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro- IGF-STAT3-HIF1 pathway in human glioblastoma cells. Biochem Pharmacol 80: 455-462, 2010.

Bombard S, Gariboldi MB, Monti E, Gabano E, Gaviglio L, Ravera M, Osella D. Biological activity of enantiomeric complexes [PtCl(2)L (2)] (L (2) is aromatic bisphosphanes and aromatic diamines). J Biol Inorg Chem 15: 841-850. 2010.

Gramatica P, Papa E, Luini M, Monti E, Gariboldi MB, Ravera M, Gabano E, Gaviglio L, Osella D. Antiproliferative Pt(IV) complexes: synthesis, biological activity and quantitative structure-activity relationship modeling. J Biol Inorg Chem 15: 1157-1169, 2010.

Alberio T, Colapinto M, Natale M, Ravizza R, Gariboldi MB, Bucci EM, Lopiano L, Fasano M. Changes in the two-dimensional electrophoresis pattern of the Parkinson's disease related protein DJ-1 in human SH-SY5Y neuroblastoma cells after dopamine treatment. IUBMB Life 62: 688-692, 2010.

Alberio T, Bossi A, Milli A, Parma E, Gariboldi M, Tosi G, Lopiano L, Fasano M. Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis. FEBS journal 277:4909-4919, 2010.

Monti E, Gariboldi MB. HIF-1 as a Target for Cancer Chemotherapy, Chemosensitization and Chemoprevention. Curr. Mol. Pharmacol. 4: 62-77, 2011.

Ravera M, Gabano E, Sardi M, Ermondi G, Caron G, McGlinchey MJ, Müller-Bunz H, Monti E, Gariboldi MB, Osella D. Synthesis, characterization, structure, molecular modeling studies and biological activity of sterically crowded Pt(II) complexes containing bis(imidazole) ligands. J. Inorg. Biochem. 105: 400-409, 2011.

Banfi S, Caruso E, Zaza S, Mancini M, Gariboldi MB, Monti E. Synthesis and photodynamic activity of a panel of BODIPY dyes. J of Photochem Photobiol B-BIOLOGY, vol. 114, p. 52- 60, 2012.

Caruso F, Rossi M, Benson A, Opazo C, Freedman D, Monti E, Gariboldi MB, Shaulky J, Marchetti F, Pettinari R, Pettinari C. Ruthenium-Arene Complexes of Curcumin: X-Ray and Density Functional Theory Structure, Synthesis, and Spectroscopic Characterization, in Vitro Antitumor Activity, and DNA Docking Studies of (p-Cymene)Ru(curcuminato)chloro. J Med Chem, vol. 55, p. 1072-1081, 2012.

Babbio F, Castiglioni I, Cassina C, Gariboldi MB, Pistore C, Magnani E, Badaracco G, Monti E, Bonapace IM. (2012). Knock-down of methyl CpG-binding protein 2 (MeCP2) causes alterations in cell proliferation and nuclear lamins expression in mammalian cells. BMC Cell Biol, vol. 13, p. 19, 2012.

Ravera M, Gabano E, Sardi M, Monti E, Gariboldi MB, Osella D. Antiproliferative Activity of PtII Complexes with Carboxylated Phosphanes in Chelated or Ring-Opened Forms. Eur J Inorg Chem, vol. 2012, p. 3441-3448, 2012 begin_of_the_skype_highlighting.

Roselli EA, Lazzati S, Isepponi F, Manganini M, Marcato L, Gariboldi MB, Maggi F, Grati FR, Simoni G. Fetal mesenchimal stromal cells from cryopreserved human chorionic villi: cytogenetic and molecular analysis of genome stability in long-term cultures. Cytotherapy, 15: 1340-1351, 2013.

Gabano E, Gama S, Mendes F, Gariboldi MB, Monti E, Bombard S, Bianco S, Ravera M. Study of the synthesis, antiproliferative properties and interaction with DNA and polynucleotides of cisplatin-like Pt(II) complexes containing carcinogenic polyaromatic amines. J Biol Inorg Chem. 2013 Oct;18(7):791-801, 2013

Solinas M, Massi P, Cinquina V, Valenti M, Bolognini D, Gariboldi M, Monti E, Rubino T, Parolaro D. Cannabidiol, a non-psychoactive compound, inhibits proliferation and invasion in U87-MG and T98G glioma cella through a multitarget effect. PLoS One 8(10):e76918, 2013.

Mancini M, Gariboldi MB, Taiana E, Bonzi C, Craparotta I, Pagin M, Monti E. Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells. British J of Cancer 110: 2865-2873, 2014.

Caruso F, Monti E, Matthews J, Rossi M, Gariboldi MB, Pettinari C, Pettinari R, Marchetti F. Synthesis, Characterization, and Antitumor Activity of Water-Soluble (Arene)ruthenium(II) Derivatives of 1,3-Dimethyl-4-acylpyrazolon-5-ato Ligands. First Example of Ru(arene)(ligand) Antitumor Species Involving Simultaneous Ru-N7(guanine) Bonding and Ligand Intercalation to DNA. Inorganic Chemistry 53: 3668-3877, 2014.

Gariboldi MB, Taiana E, Bonzi MC, Craparotta I, Giovannardi S, Mancini M, Monti E. The BH3-mimetic obatoclax reduces HIF-1α levels and HIF-1 transcriptional activity and sensitizes hypoxic colon adenocarcinoma cells to 5-fluorouracil. Cancer Lett. 364:156-164, 2015.

Lualdi M, Pedrini E, Rea K, Monti L, Scaldaferri D, Gariboldi M, Camporeale A, Ghia P, Monti E, Tomassetti A, Acquati F, Taramelli R. Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase. Oncotarget 6:7851-7865, 2015.

Caruso F, Pettinari R, Rossi M, Monti E, Gariboldi MB, Marchetti F, Pettinari C, Caruso A, Ramani MV, Subbaraju GV. The in vitro antitumor activity of arene.ruthenium(II) curcuminoid complexes improves when decreasing curcumin polarity. J Inorg Biochem. 162: 44-51, 2016.

Ferroni C, Sotgiu G, Sagnella A, Varchi G, Guerrini A, Polo E, Orlandi V, Marras E, Gariboldi, M, Monti E, Aluigi, A. Wool keratin 3D scaffolds with light-triggered antimicrobial activity. Biomacromolecules. 17(9):2882-90, 2016.

Enrico Caruso, Marzia Bruna Gariboldi, Paola Gramatica, Alessandro Sangion, Stefano Banfi. Synthesis, Photodynamic activity, and Quantitative Structure-Activity Relationship Modeling of a series of BODIPYs. Journal of Photochemistry & Photobiology, B: Biology, 167: 269-281, 2017.

ELENCO DELLE PUBBLICAZIONI - Capitoli di libri

Pommier Y., Fujimori A., Hoki Y., Gupta M. and Gariboldi M. DNA Topoisomerase I inhibitors and multidrug resistance. In Gupta S. and Tsuruo T. (Eds.): Multidrug resistance in cancer cells, John Willey Oxford, pp 119-135, 1996.

Monti E, Gariboldi MB, Ravizza R, Molteni R, Gabano E, Sparnacci K, Laus M, Osella D. Assessment of the in vivo antiproliferative activity of a novel platinum particulate pharmacophore. In: Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy Molecular Mechanisms and Clinical Applications. Series: Cancer Drug Discovery and Development. Bonetti, A.; Leone, R.; Muggia, F.; Howell, S.B. (Eds.). pp 19-25, 2009.