FERRARI MARCO | Università degli studi dell'Insubria

E-mail

[email protected]

Numero telefonico

0332 39 7414

BIOGRAPHICAL SKETCH

Name: Ferrari Marco

Birth: In Busto Arsizio (VA, Italy), March 25th, 1971

Citizenship: Italian

Mail: [email protected]

Tel. 0039 0332 217414

Fax: 0039 0332 217409

EDUCATION

1990: High School degree at Technical Institute “Cipriano Facchinetti”.

DEGREES

· 1995: BSC University of Milano Faculty of SMFN, with honours.

· 2001: Qualification of Pharmacology (University of Pavia, Italy, School of Pharmacology 50/50 magna cum laude).

· 2009: PhD in Pharmacology (University of Insubria, Vares, Italy).

PROFESSIONAL EXPERIENCE

· 1998-1999: University of Insubria, Laboratory of Pharmacology, Research contract: “Possibile ruolo di meccanismi adrenergici autocrini e paracrini nella regolazione della funzionalità dei leucociti”.

· 2000-2001: University of Insubria, Laboratory of Pharmacology, Research contract: “Alterazioni neuroimmunologiche nei disturbi motori dell’apparato gastroenterico”.

· 2001-2002: University of Insubria, Laboratory of Pharmacology, Research contract: “studio dei meccanismi recettoriali e post-recettoriali implicati nella sintesi e nella liberazione di catecolamine dai linfociti umani”.

· 2003-2005: technician assistant contract, University of Insubria, Department of Internal Medicine - section of Experimental and Clinical Pharmacology.

CURRENT POSITION

2006-date: Assistant Professor in Pharmacology (University of Insubria, department of Internal Medicine - Section of Experimental and Clinical Pharmacology).

SCIENTIFIC SOCIETY

· Italian Society of Pharmacology (SIF).

· WAGEM - World Association of Genomic Medicine.

APPOINTMENTS

· 2004-2013. Member of the Ethics Committees of the S. Anna hospital, Como, Italy.

· 2013-date. Member of the Drug Commission of the S. Anna hospital, Como, Italy.

Ricerca

Portale IRInSubria

Pubblicazioni in evidenza

1: Cosentino M, Ferrari M, Kustrimovic N, Rasini E, Marino F. Influence of
dopamine receptor gene polymorphisms on circulating T lymphocytes: A pilot study
in healthy subjects. Hum Immunol. 2015 Sep 30. pii: S0198-8859(15)00469-3. doi:
10.1016/j.humimm.2015.09.032. [Epub ahead of print] PubMed PMID: 26429319.

2: Ferrari M, Romualdi E, Dentali F, Squizzato A, Marino F, Cosentino M, Ageno W.
Association between ABCG2 and ABCB1 genes and warfarin stability: a case-control
study. Thromb Res. 2014 Dec;134(6):1359-62. doi: 10.1016/j.thromres.2014.09.017.
Epub 2014 Sep 20. PubMed PMID: 25300812.

3: Ferrari M, Guasti L, Maresca A, Mirabile M, Contini S, Grandi AM, Marino F,
Cosentino M. Association between statin-induced creatine kinase elevation and
genetic polymorphisms in SLCO1B1, ABCB1 and ABCG2. Eur J Clin Pharmacol. 2014
May;70(5):539-47. doi: 10.1007/s00228-014-1661-6. Epub 2014 Mar 6. PubMed PMID:
24595600.

4: Ferrari M, Bolla E, Bortolaso P, Callegari C, Poloni N, Lecchini S, Vender S,
Marino F, Cosentino M. Association between CYP1A2 polymorphisms and
clozapine-induced adverse reactions in patients with schizophrenia. Psychiatry
Res. 2012 Dec 30;200(2-3):1014-7. doi: 10.1016/j.psychres.2012.07.002. Epub 2012
Aug 16. PubMed PMID: 22901441.

5: Ferrari M, Martignoni E, Blandini F, Riboldazzi G, Bono G, Marino F, Cosentino
M. Association of UDP-glucuronosyltransferase 1A9 polymorphisms with adverse
reactions to catechol-O-methyltransferase inhibitors in Parkinson's disease
patients. Eur J Clin Pharmacol. 2012 Nov;68(11):1493-9. doi:
10.1007/s00228-012-1281-y. Epub 2012 Apr 15. PubMed PMID: 22527346.

6: Cosentino M, Zaffaroni M, Trojano M, Giorelli M, Pica C, Rasini E, Bombelli R,
Ferrari M, Ghezzi A, Comi G, Livrea P, Lecchini S, Marino F. Dopaminergic
modulation of CD4+CD25(high) regulatory T lymphocytes in multiple sclerosis
patients during interferon-β therapy. Neuroimmunomodulation. 2012;19(5):283-92.
doi: 10.1159/000336981. Epub 2012 Apr 3. PubMed PMID: 22472872.

7: Bolla E, Bortolaso P, Ferrari M, Poloni N, Callegari C, Marino F, Lecchini S,
Vender S, Cosentino M. Are CYP1A2*1F and *1C associated with clozapine
tolerability?: a preliminary investigation. Psychiatry Res. 2011 Oct
30;189(3):483. doi: 10.1016/j.psychres.2011.03.011. Epub 2011 Apr 8. PubMed PMID:
21481946.

8: Cosentino M, Colombo C, Mauri M, Ferrari M, Corbetta S, Marino F, Bono G,
Lecchini S. Expression of apoptosis-related proteins and of mRNA for dopaminergic
receptors in peripheral blood mononuclear cells from patients with Alzheimer
disease. Alzheimer Dis Assoc Disord. 2009 Jan-Mar;23(1):88-90. PubMed PMID:
19266703.

9: Zaffaroni M, Marino F, Bombelli R, Rasini E, Monti M, Ferrari M, Ghezzi A,
Comi G, Lecchini S, Cosentino M. Therapy with interferon-beta modulates
endogenous catecholamines in lymphocytes of patients with multiple sclerosis. Exp
Neurol. 2008 Dec;214(2):315-21. doi: 10.1016/j.expneurol.2008.08.015. Epub 2008
Sep 12. PubMed PMID: 18824168.

10: Marino F, Guasti L, Cosentino M, Rasini E, Ferrari M, Maio RC, Loraschi A,
Cimpanelli MG, Schembri L, Legnaro M, Molteni E, Crespi C, Crema F, Venco A,
Lecchini S. Simvastatin treatment in subjects at high cardiovascular risk
modulates AT1R expression on circulating monocytes and T lymphocytes. J
Hypertens. 2008 Jun;26(6):1147-55. doi: 10.1097/HJH.0b013e3282f97dde. PubMed
PMID: 18475152.

11: Guasti L, Marino F, Cosentino M, Maio RC, Rasini E, Ferrari M, Castiglioni L,
Klersy C, Gaudio G, Grandi AM, Lecchini S, Venco A. Prolonged statin-associated
reduction in neutrophil reactive oxygen species and angiotensin II type 1
receptor expression: 1-year follow-up. Eur Heart J. 2008 May;29(9):1118-26. doi:
10.1093/eurheartj/ehn138. Epub 2008 Apr 3. PubMed PMID: 18390537.

12: Ferrari M, Termine C, Franciotta D, Castiglioni E, Pagani A, Lanzi G, Marino
F, Lecchini S, Cosentino M, Balottin U. Dopaminergic receptor D5 mRNA expression
is increased in circulating lymphocytes of Tourette syndrome patients. J
Psychiatr Res. 2008 Nov;43(1):24-9. doi: 10.1016/j.jpsychires.2008.01.014. Epub
2008 Mar 7. PubMed PMID: 18329046.

13: Cosentino M, Marino F, Ferrari M, Rasini E, Bombelli R, Luini A, Legnaro M,
Delle Canne MG, Luzzani M, Crema F, Paracchini S, Lecchini S. Estrogenic activity
of 7-hydroxymatairesinol potassium acetate (HMR/lignan) from Norway spruce (Picea
abies) knots and of its active metabolite enterolactone in MCF-7 cells. Pharmacol
Res. 2007 Aug;56(2):140-7. Epub 2007 May 22. PubMed PMID: 17572100.

14: Marino F, Guasti L, Cosentino M, Ferrari M, Rasini E, Maio RC, Cimpanelli MG,
Cereda E, Crespi C, Simoni C, Restelli D, Venco A, Lecchini S. Angiotensin II
type 1 receptor expression in polymorphonuclear leukocytes from high-risk
subjects: changes after treatment with simvastatin. J Cardiovasc Pharmacol. 2007
May;49(5):299-305. PubMed PMID: 17513949.

15: Guasti L, Marino F, Cosentino M, Cimpanelli M, Piantanida E, Mainardi LT,
Vanoli P, De Palma D, Bombelli R, Ferrari M, Crespi C, Simoni C, Klersy C, Gaudio
G, Maroni L, Grandi AM, Tanda M, Bartalena L, Cerutti S, Lecchini S, Venco A.
Changes in autonomic modulation to the heart and intracellular catecholamines. A
longitudinal study in differentiated thyroid carcinoma during short-term
hypothyroidism and thyroid hormone replacement. Horm Res. 2007;67(4):171-8. Epub
2006 Nov 13. PubMed PMID: 17106203.

16: Cosentino M, Fietta AM, Ferrari M, Rasini E, Bombelli R, Carcano E, Saporiti
F, Meloni F, Marino F, Lecchini S. Human CD4+CD25+ regulatory T cells selectively
express tyrosine hydroxylase and contain endogenous catecholamines subserving an
autocrine/paracrine inhibitory functional loop. Blood. 2007 Jan 15;109(2):632-42.
Epub 2006 Sep 19. PubMed PMID: 16985181.

17: Meloni F, Morosini M, Solari N, Passadore I, Nascimbene C, Novo M, Ferrari M,
Cosentino M, Marino F, Pozzi E, Fietta AM. Foxp3 expressing CD4+ CD25+ and
CD8+CD28- T regulatory cells in the peripheral blood of patients with lung cancer
and pleural mesothelioma. Hum Immunol. 2006 Jan-Feb;67(1-2):1-12. Epub 2006 Mar
31. PubMed PMID: 16698419.

18: Rasini E, Cosentino M, Marino F, Legnaro M, Ferrari M, Guasti L, Venco A,
Lecchini S. Angiotensin II type 1 receptor expression on human leukocyte subsets:
a flow cytometric and RT-PCR study. Regul Pept. 2006 May 15;134(2-3):69-74. Epub
2006 Mar 13. PubMed PMID: 16530863.

19: Martignoni E, Cosentino M, Ferrari M, Porta G, Mattarucchi E, Marino F,
Lecchini S, Nappi G. Two patients with COMT inhibitor-induced hepatic dysfunction
and UGT1A9 genetic polymorphism. Neurology. 2005 Dec 13;65(11):1820-2. PubMed
PMID: 16344532.

20: Cosentino M, Zaffaroni M, Ferrari M, Marino F, Bombelli R, Rasini E, Frigo G,
Ghezzi A, Comi G, Lecchini S. Interferon-gamma and interferon-beta affect
endogenous catecholamines in human peripheral blood mononuclear cells:
implications for multiple sclerosis. J Neuroimmunol. 2005 May;162(1-2):112-21.
PubMed PMID: 15833366.

21: Marino F, Cosentino M, Ferrari M, Cattaneo S, Frigo G, Fietta AM, Lecchini S,
Frigo GM. Intracellular calcium changes induced by the endozepine
triakontatetraneuropeptide in human polymorphonuclear leukocytes: role of protein
kinase C and effect of calcium channel blockers. Cell Commun Signal. 2004 Jun
30;2(1):6. PubMed PMID: 15228623; PubMed Central PMCID: PMC449738.

22: Cosentino M, Zaffaroni M, Giorelli M, Marino F, Ferrari M, Bombelli R, Rasini
E, Trojano M, Lecchini S, Livrea P, Comi G, Frigo G. Adrenergic mechanisms in
multiple sclerosis: the neuro-immune connection? Trends Pharmacol Sci. 2004
Jul;25(7):350-1; author reply 351-2. PubMed PMID: 15219975.

23: Cosentino M, Rasini E, Colombo C, Marino F, Blandini F, Ferrari M, Samuele A,
Lecchini S, Nappi G, Frigo G. Dopaminergic modulation of oxidative stress and
apoptosis in human peripheral blood lymphocytes: evidence for a D1-like
receptor-dependent protective effect. Free Radic Biol Med. 2004 May
15;36(10):1233-40. PubMed PMID: 15110388.

24: Ferrari M, Cosentino M, Marino F, Bombelli R, Rasini E, Lecchini S, Frigo G.
Dopaminergic D1-like receptor-dependent inhibition of tyrosine hydroxylase mRNA
expression and catecholamine production in human lymphocytes. Biochem Pharmacol.
2004 Mar 1;67(5):865-73. PubMed PMID: 15104239.

25: Colombo C, Cosentino M, Marino F, Rasini E, Ossola M, Blandini F, Mangiagalli
A, Samuele A, Ferrari M, Bombelli R, Lecchini S, Nappi G, Frigo G. Dopaminergic
modulation of apoptosis in human peripheral blood mononuclear cells: possible
relevance for Parkinson's disease. Ann N Y Acad Sci. 2003 Dec;1010:679-82. PubMed
PMID: 15033811.

26: Cosentino M, Marino F, Bombelli R, Ferrari M, Lecchini S, Frigo G.
Unravelling dopamine (and catecholamine) physiopharmacology in lymphocytes: open
questions. Trends Immunol. 2003 Nov;24(11):581-2; author reply 582-3. PubMed
PMID: 14596880.

27: Marino F, Cosentino M, Fietta AM, Ferrari M, Cattaneo S, Frigo G, Lecchini S,
Frigo GM. Interleukin-8 production induced by the endozepine
triakontatetraneuropeptide in human neutrophils: role of calcium and
pharmacological investigation of signal transduction pathways. Cell Signal. 2003
May;15(5):511-7. PubMed PMID: 12639714.

28: Reguzzoni M, Cosentino M, Rasini E, Marino F, Ferrari M, Bombelli R, Congiu
T, Protasoni M, Quacci D, Lecchini S, Raspanti M, Frigo G. Ultrastructural
localization of tyrosine hydroxylase in human peripheral blood mononuclear cells:
effect of stimulation with phytohaemagglutinin. Cell Tissue Res. 2002
Dec;310(3):297-304. Epub 2002 Oct 23. PubMed PMID: 12457228.

29: Cosentino M, Zaffaroni M, Marino F, Bombelli R, Ferrari M, Rasini E, Lecchini
S, Ghezzi A, Frigo G. Catecholamine production and tyrosine hydroxylase
expression in peripheral blood mononuclear cells from multiple sclerosis
patients: effect of cell stimulation and possible relevance for
activation-induced apoptosis. J Neuroimmunol. 2002 Dec;133(1-2):233-40. PubMed
PMID: 12446028.

30: Cosentino M, Marino F, Bombelli R, Ferrari M, Rasini E, Lecchini S, Frigo G.
Stimulation with phytohaemagglutinin induces the synthesis of catecholamines in
human peripheral blood mononuclear cells: role of protein kinase C and
contribution of intracellular calcium. J Neuroimmunol. 2002 Apr;125(1-2):125-33.
PubMed PMID: 11960648.

31: Conti A, Maestroni GJ, Cosentino M, Frigo GM, Lecchini S, Marino F, Bombelli
R, Ferrari M, Brivio F, Roselli MG, Lissoni P. Evidence for a
neuroimmunomodulatory and a hematopoietic role of the Luschka's coccygeal
body(3). Neuro Endocrinol Lett. 2000;21(5):391-403. PubMed PMID: 11452233.

32: Cosentino M, Bombelli R, Ferrari M, Marino F, Rasini E, Maestroni GJ, Conti
A, Boveri M, Lecchini S, Frigo G. HPLC-ED measurement of endogenous
catecholamines in human immune cells and hematopoietic cell lines. Life Sci. 2000
Dec 8;68(3):283-95. PubMed PMID: 11191644.

33: Giaroni C, Zanetti E, Marino F, Cosentino M, Senaldi A, Somaini L, Ferrari M,
Bombelli R, Lecchini S, Frigo G. Glutamate receptors of the AMPA type modulate
neurotransmitter release and peristalsis in the guinea-pig isolated colon. Life
Sci. 2000 Aug 25;67(14):1747-57. PubMed PMID: 11021359.

34: Cosentino M, Marino F, Bombelli R, Ferrari M, Lecchini S, Frigo G. Endogenous
catecholamine synthesis, metabolism, storage and uptake in human neutrophils.
Life Sci. 1999;64(11):975-81. PubMed PMID: 10201646.

35: Marino F, Cosentino M, Bombelli R, Ferrari M, Lecchini S, Frigo G. Endogenous
catecholamine synthesis, metabolism storage, and uptake in human peripheral blood
mononuclear cells. Exp Hematol. 1999 Mar;27(3):489-95. PubMed PMID: 10089911.

36: Marino F, Cosentino M, De Ponti F, Giaroni C, Somaini L, Bombelli R, Ferrari
M, Aasen AJ, Lecchini S, Frigo G. Muscarinic modulation of endogenous
noradrenaline release from adrenergic terminals in the guinea-pig colon. J Auton
Pharmacol. 1997 Dec;17(6):365-72. PubMed PMID: 9610431.

37: Cosentino M, Marino F, Bombelli R, Ferrari M, Maestroni GJ, Conti A, Rasini
E, Lecchini S, Frigo G. Association between the circadian course of endogenous
noradrenaline and the hematopoietic cell cycle in mouse bone marrow. J Chemother.
1998 Apr;10(2):179-81. PubMed PMID: 9603652.

38: Marino F, Cosentino M, Bombelli R, Ferrari M, Maestroni GJ, Conti A, Lecchini
S, Frigo G. Measurement of catecholamines in mouse bone marrow by means of HPLC
with electrochemical detection. Haematologica. 1997 Jul-Aug;82(4):392-4. PubMed
PMID: 9299848.

39: Cosentino M, Marino F, Bombelli R, Ferrari M, Rasini E, Giaroni C, Lecchini
S, Frigo G. Modulation of neurotransmitter release by opioid mu- and
kappa-receptors from adrenergic terminals in the myenteric plexus of the
guinea-pig colon: effect of alpha 2-autoreceptor blockade. Neurosci Lett. 1997
Jan 31;222(2):75-8. PubMed PMID: 9111732.